Bacterial DNA in mRNA vaccines: its epigenetics and incomplete linearization

What happens when bacterially methylated plasmid DNA meets the human innate immune system?
This video explores sequencing data from Pfizer lot FL8095, showing residual plasmid DNA bearing bacterial epigenetic marks — and what that could mean for immune signaling, inflammation, and future manufacturing standards.

⏱️ Timestamps:
00:00 – Intro and video title
00:24 – Bacterial DNA contamination background
07:25 – Bacterial plasmid DNA fragments size distribution
09:15 – Methylation pattern of bacterial plasmid fragments
11:39 – Non-linearization of the plasmid and its implications

📍 Filming Location: Isaac's Wet Dream Waterfall, Alberta

📄 Described content:
https://zenodo.org/records/17281691

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#mRNA #PlasmidDNA #Epigenetics #cGAS #STINGPathway #VaccineScience #Immunology #Biotech #Nanopore #DNASequencing #InnateImmunity #Methylation #MolecularBiology #SV40 #Pfizer